标签：FosB direct brain addict address addiction adequate

addict

Addiction is a biopsychosocial disorder characterized by repeated use of drugs, or repetitive engagement in a behavior such as gambling, despite harm to self and others. According to the "brain disease model of addiction," while a number of psychosocial factors contribute to the development and maintenance of addiction, a biological process that is induced by repeated exposure to an addictive stimulus is the core pathology that drives the development and maintenance of an addiction. Many scholars who study addiction argue that the brain disease model is incomplete and misleading.

The brain disease model posits that addiction is a disorder of the brain's reward system which arises through transcriptional and epigenetic mechanisms and develops over time from chronically high levels of exposure to an addictive stimulus (e.g., eating food, the use of cocaine, engagement in sexual activity, participation in high-thrill cultural activities such as gambling, etc.). DeltaFosB (ΔFosB), a gene transcription factor, is a critical component and common factor in the development of virtually all forms of behavioral and drug addictions. Two decades of research into ΔFosB's role in addiction have demonstrated that addiction arises, and the associated compulsive behavior intensifies or attenuates, along with the overexpression of ΔFosB in the D1-type medium spiny neurons of the nucleus accumbens. Due to the causal relationship between ΔFosB expression and addictions, it is used preclinically as an addiction biomarker. ΔFosB expression in these neurons directly and positively regulates drug self-administration and reward sensitization through positive reinforcement, while decreasing sensitivity to aversion.

六级/考研单词: engage, gamble, despite, accord, induce, scholar, mislead, chronic, cocaine, component, medium, regulate, reinforce, decrease, avert

address

1. "to guide, aim, or direct," e.g. to address a golf ball
2. "direct for transmission, write as a destination on a message"
The letter was addressed to Penny.
3. to direct spoken words (to someone)
Leonard turned to address the one on his right.
4. "to set in order, repair, correct."
Our sweeping robot, Spreadshit(展屎官) addresses the needs of 铲屎官们.

写地址有曲里拐弯的吗？

adequate

词源: equal to what is needed or desired
近/反义词: just good enough, mediocre, satisfactory, sufficient; deficient, inadequate, insufficient

My old laptop is still more than adequate for most tasks.

How: really, very, perfectly, quite, totally, more than; almost; barely, hardly, less than, not entirely/wholly; still, no longer

标签：FosB,direct,brain,addict,address,addiction,adequate
来源： https://www.cnblogs.com/funwithwords/p/15613794.html

本站声明： 1. iCode9 技术分享网（下文简称本站）提供的所有内容，仅供技术学习、探讨和分享；
2. 关于本站的所有留言、评论、转载及引用，纯属内容发起人的个人观点，与本站观点和立场无关；
3. 关于本站的所有言论和文字，纯属内容发起人的个人观点，与本站观点和立场无关；
4. 本站文章均是网友提供，不完全保证技术分享内容的完整性、准确性、时效性、风险性和版权归属；如您发现该文章侵犯了您的权益，可联系我们第一时间进行删除；
5. 本站为非盈利性的个人网站，所有内容不会用来进行牟利，也不会利用任何形式的广告来间接获益，纯粹是为了广大技术爱好者提供技术内容和技术思想的分享性交流网站。